Effects of prophylaxis with mDEF201 on percent body weights of mice during vaccinia virus (WR strain) respiratory infections.

<p>(A) Experiment 1, primary infection, (B) Experiment 1, reinfection, (C) Experiment 2, primary infection, (D) Experiment 2, reinfection. Intranasal treatments with mDEF201 (10⁷ PFU/mouse) were given one time only on the indicated day prior to virus exposure. In Experiment 1 the primary intranasal challenge was 1×10⁵ PFU of virus. Since this challenge dose failed to cause 100% mortality (as mice age their susceptibility to infection wanes), the primary virus challenge dose was increased to 2.5×10⁵ PFU of virus for Experiment 2. Reinfection of both sets of mice was performed intranasally with 5×10⁵ PFU of virus. The data accompany those of <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0026330#pone-0026330-t002" target="_blank">Table 2</a>. Thus, the initial number of mice per group for each figure corresponds to the total number per group in the table.