<p>A - Schematic presentation of the double-chamber plethysmographic set-up allowing the simultaneous recordings of chest spirogram (CSp; in the body chamber) and airflow spirogram (ASp; in the head chamber) in conscious mice. B, C – Averaging of about 100 successive respiratory cycles during quiet period of breathing in young (B) and old (C) mice allowed the measurements of mean ASp and CSp, the calculation of the ASp/CSp ratio and the measurement of expiratory airflow during lung emptying period (gray areas). D - Columns in histograms show the ASp/CSp ratio in Tau.P301L (black columns) and FVB/N (white columns) young and old mice. Note 1) the ratio was similar in young Tau.P301L and FVB/N mice, and 2) the ratio was significantly reduced a...
There are invasive and noninvasive pulmonary function tests available which are sensitive in detecti...
<p>Longitudinal midline sections of tracheas from young (4–7month) and old (24–26 month) male C57Bl/...
<p>Airway wall area (A), airway smooth muscle area (B), and airway epithelium area (C) were not sign...
<p>Mean ± SEM values expressed in mL/g/s for expiratory airflow (Exp Airflow), cycle per min for res...
We examined developmental changes in breathing pattern and the ventilatory response to hypoxia (7.4%...
In this thesis we explore and further develop several techniques used in the animal laboratory as we...
Most studies using mice to model human lung diseases are carried out in adults, although there is em...
Previous studies have shown a blunted ventilatory response to hypercapnia in mdx mice older than 7 m...
peer reviewedDouble-chamber plethysmography has been recognized since 1979 as a reference technique ...
To assess the contribution of genetic background to respiratory mechanics, we developed a ventilator...
<p>(A) Lung sections stained with periodic acid-Schiff (PAS) and elastic van Gieson's (EVG) stains. ...
The laboratory mouse has developed into the preferred model system for biomedical lung research. The...
Mice deficient in surfactant protein D [SP-D (-/-)] develop progressive emphysema with age, associat...
peer reviewedTo assess the contribution of genetic background to respiratory mechanics, we developed...
Purpose: Duchenne Muscular Dystrophy (DMD) is an incurable disease affecting one in 2,500 boys. DMD ...
There are invasive and noninvasive pulmonary function tests available which are sensitive in detecti...
<p>Longitudinal midline sections of tracheas from young (4–7month) and old (24–26 month) male C57Bl/...
<p>Airway wall area (A), airway smooth muscle area (B), and airway epithelium area (C) were not sign...
<p>Mean ± SEM values expressed in mL/g/s for expiratory airflow (Exp Airflow), cycle per min for res...
We examined developmental changes in breathing pattern and the ventilatory response to hypoxia (7.4%...
In this thesis we explore and further develop several techniques used in the animal laboratory as we...
Most studies using mice to model human lung diseases are carried out in adults, although there is em...
Previous studies have shown a blunted ventilatory response to hypercapnia in mdx mice older than 7 m...
peer reviewedDouble-chamber plethysmography has been recognized since 1979 as a reference technique ...
To assess the contribution of genetic background to respiratory mechanics, we developed a ventilator...
<p>(A) Lung sections stained with periodic acid-Schiff (PAS) and elastic van Gieson's (EVG) stains. ...
The laboratory mouse has developed into the preferred model system for biomedical lung research. The...
Mice deficient in surfactant protein D [SP-D (-/-)] develop progressive emphysema with age, associat...
peer reviewedTo assess the contribution of genetic background to respiratory mechanics, we developed...
Purpose: Duchenne Muscular Dystrophy (DMD) is an incurable disease affecting one in 2,500 boys. DMD ...
There are invasive and noninvasive pulmonary function tests available which are sensitive in detecti...
<p>Longitudinal midline sections of tracheas from young (4–7month) and old (24–26 month) male C57Bl/...
<p>Airway wall area (A), airway smooth muscle area (B), and airway epithelium area (C) were not sign...