MR blockade prior to brief context re-exposure reduces subsequent fear expression.

<p>A) Behavioral procedure for the experiment. B) Freezing behavior in both vehicle and spironolactone treated mice decreased both on day 3 and one month later when compared to day 2. Treating mice with spironolactone one hour before brief (3 minutes) retrieval (day 2) reduced freezing behavior compared to vehicle treated mice, both during the retrieval session and one day later (day 3). <b>^#</b> and <b>^##</b> reflect P<0.05 and P<0.01 respectively when compared to day 2; *and**reflect P<0.05 and P<0.01 respectively when compared to vehicle treated mice at the same time point (n = 9 mice per group).