Effects of pallidal infusion of a dopamine D2-like agonist on PPI.

<p>A dopamine D2-like agonist, quinpirole (QUIN) (5 µg per site), or vehicle was administered to both hemispheres of the GP of naïve rats. (A) Cannula placement was confirmed in fixed brains, and one out of 18 rats was excluded from the final data analysis due to incorrect cannula placement. Fifteen minutes after quinpirole injection, pulse-alone startles (B) and PPI scores (C) were measured with 75-, 80- and 85-dB prepulse stimuli combined with a 120-dB startle tone. Bars indicate mean ± SEM (n = 8 or 9 each). *p<0.05, **p<0.01, compared with vehicle-infused controls by Fisher LSD.