Renal medullary tissue levels of 20-HETE in response to blockade of medullary ET-B receptors.

<p>In response to increasing salt intake in male SD rats, renal medullary 20-HETE levels are significantly elevated (5.6±0.75 vs. 14.3±3.7, n = 4 and n = 7 respectively). With chronic intramedullary blockade of ET-B receptors, this response is completely abolished (4.9±0.79 vs. 4.5±0.55, n = 5 and n = 6 respectively). * denotes p<.05 vs. NS + VEH.