Effect of PYY gene transfer to the salivary glands in C57Bl/6J mice.
- Andres Acosta (305512)
- Maria D. Hurtado (305511)
- Oleg Gorbatyuk (342280)
- Michael La Sala (342282)
- David Duncan (154608)
- George Aslanidi (342284)
- Martha Campbell-Thompson (342286)
- Lei Zhang (38117)
- Herbert Herzog (153845)
- Antonis Voutetakis (342288)
- Bruce J. Baum (305516)
- Sergei Zolotukhin (50135)
Publication date
February 2013
DOIAbstract
<p><i>(A)</i> Concentration of PYY<sub>3-36</sub> in plasma during fasting and after feeding. <i>(B)</i> Concentration of PYY<sub>3-36</sub> in saliva. <i>(C)</i> Effect of PYY<sub>3-36</sub> salivary gland gene delivery on weekly FI in mice fed HF diet. <i>(D)</i> Effect of PYY<sub>3-36</sub> salivary gland gene delivery on weekly FI in DIO mice. <i>(E)</i> BW change in DIO C57Bl/6J treated with rAAV-GFP (control group) and rAAV-PYY over 8 weeks post injection. <i>(F)</i> Weight of visceral white adipose tissue at 8 weeks post injection in mice treated with rAAV (all groups were 10 animals/group) *P<0.05.</p
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