<p><b>A</b>) Rescue of dauer defective phenotype of <i>C. elegans daf-2;daf-16</i> mutants by <i>Ac</i>-DAF-16 wildtype and AKT phosphorylation mutants at 25°C. <b>B</b>) Chi-square analysis of A) showing significant p-values in bolt. <b>C</b>) Recovery of SDS isolated dauers complemented with <i>Ac</i>-DAF-16 wildtype and AKT phospho-mutants at 16°C. <b>D</b>) Chi-square analysis of C.</p
MasterInsulin/IGF-1 signaling is one of the well-described and evolutionarily conserved longevity-me...
<p>(A) Mutations in <i>daf-16</i> (<i>daf-16(mgDf47)</i>) or <i>daf-12</i> (<i>daf-12(rh61rh411)</i>...
<p><b>(A)</b> Protein alignment of the two isoforms of <i>C</i>. <i>elegans</i> CGI-58 (C37H5.a and ...
<p>Pictures are lambda stack images from transgenic <i>daf-2;daf-16</i> dauers, expressing fusion co...
<p>Pictures are lambda stack images from transgenic <i>daf-2;daf-16</i> dauers, expressing fusion co...
It is well established that the C. elegans insulin/IGF-1 receptor tyrosine kinase DAF-2 acts though ...
<p>Dauer larvae showing nuclear and nuclear/cytoplasmic <i>Ac</i>-DAF-16::GFP were quantified during...
<p>(A) Survival curves of wild-type (black) and <i>tdp-1(ok803lf)</i> loss-of-function mutant (red) ...
<p><i>eak</i> single mutants, <i>eak-x;eak-y</i> double mutants, or <i>eak;akt-1</i> double mutants ...
Parasitic hookworms and the free-living model nematode Caenorhabtidis elegans share a developmental ...
Parasitic hookworms and the free-living model nematode Caenorhabtidis elegans share a developmental ...
We recently discovered that the genotypes of several strains that we reported as daf-16(mu86) actual...
All strains were maintained at 15°C using standard C. elegans techniques (Stiernagle, 2006). Double ...
Parasitic hookworms and the free-living model nematode Caenorhabtidis elegans share a developmental ...
<p>(A) For dauer formation in <i>C. elegans</i> the <i>daf-2</i>/IGFR receptor lies upstream of a PI...
MasterInsulin/IGF-1 signaling is one of the well-described and evolutionarily conserved longevity-me...
<p>(A) Mutations in <i>daf-16</i> (<i>daf-16(mgDf47)</i>) or <i>daf-12</i> (<i>daf-12(rh61rh411)</i>...
<p><b>(A)</b> Protein alignment of the two isoforms of <i>C</i>. <i>elegans</i> CGI-58 (C37H5.a and ...
<p>Pictures are lambda stack images from transgenic <i>daf-2;daf-16</i> dauers, expressing fusion co...
<p>Pictures are lambda stack images from transgenic <i>daf-2;daf-16</i> dauers, expressing fusion co...
It is well established that the C. elegans insulin/IGF-1 receptor tyrosine kinase DAF-2 acts though ...
<p>Dauer larvae showing nuclear and nuclear/cytoplasmic <i>Ac</i>-DAF-16::GFP were quantified during...
<p>(A) Survival curves of wild-type (black) and <i>tdp-1(ok803lf)</i> loss-of-function mutant (red) ...
<p><i>eak</i> single mutants, <i>eak-x;eak-y</i> double mutants, or <i>eak;akt-1</i> double mutants ...
Parasitic hookworms and the free-living model nematode Caenorhabtidis elegans share a developmental ...
Parasitic hookworms and the free-living model nematode Caenorhabtidis elegans share a developmental ...
We recently discovered that the genotypes of several strains that we reported as daf-16(mu86) actual...
All strains were maintained at 15°C using standard C. elegans techniques (Stiernagle, 2006). Double ...
Parasitic hookworms and the free-living model nematode Caenorhabtidis elegans share a developmental ...
<p>(A) For dauer formation in <i>C. elegans</i> the <i>daf-2</i>/IGFR receptor lies upstream of a PI...
MasterInsulin/IGF-1 signaling is one of the well-described and evolutionarily conserved longevity-me...
<p>(A) Mutations in <i>daf-16</i> (<i>daf-16(mgDf47)</i>) or <i>daf-12</i> (<i>daf-12(rh61rh411)</i>...
<p><b>(A)</b> Protein alignment of the two isoforms of <i>C</i>. <i>elegans</i> CGI-58 (C37H5.a and ...