Suppression of CRMP5 expression in CRMP5^−/− mice increases cell proliferation in the adult brain neurogenic areas.

<p>(<b>A,B</b>) Immunofluorescence detection of CRMP5 in the dentate gyrus (3A) and SVZ (3B) confirms the lack of CRMP5 expression in CRMP5^−/− mice in comparison to wild type mice (WT). (<b>C</b>) Immunocytochemical labeling of BrdU-positive cells in the SGZ of the dentate gyrus (DG) of WT and CRMP5^−/− mice, 2 hours after BrdU injections. Hilus (Hi); Granular cell layer (GCL). Scale bar 100 µm. (<b>D</b>) Increased total number of BrdU positive cells in the DG of CRMP5^−/− mice. Values are expressed as mean + SEM. Student t-test. * p<0.05; ** p<0.01. (<b>E</b>) Immunocytochemical labeling of BrdU-positive cells in the subventricular zone (SVZ) of WT and CRMP5^−/− mice, 2 hours after BrdU injections. Lateral ventricles (LV). Scale bar 100 µm. (<b>F</b>) Increased total number of BrdU positive cells in the SVZ of CRMP5^−/− mice. Values are expressed as mean + SEM. Student t-test. * p<0.05; ** p<0.01.