CD68^−/− mice have increased trabecular bone and decreased trabecular tissue mineral density.

<p>(A) Representative trabecular µCT images from 6-month-old female mice of each genotype (5 mice per group). (B) µCT analysis of distal femoral trabecular bone revealed that CD68^−/− mice have increased bone volume (BV/TV), increased trabecular number (Tb. N), decreased trabecular spacing (Tb. Sp.) and decreased trabecular tissue mineral density (Trabecular TMD). There was no significant difference in trabecular thickness (Tb. Th.). (C) Representative cortical µCT images from each genotype. (D) Quantification of measured parameters. There was no significant difference between genotypes in either cortical thickness (Ct. Th.) or cortical tissue mineral density (Cortical TMD). *, p<.05; **, p<.01. Data presented are means + standard deviation.