Affinities (K<sub>D</sub>) and kinetic parameters (k<sub>a</sub> and k<sub>d</sub>) for six selected affinity matured binding molecules.
- Johan Nilvebrant (342908)
- Tove Alm (342909)
- Sophia Hober (217348)
- John Löfblom (110216)
Publication date
February 2013
DOIAbstract
<p>ABD<sub>T001</sub>, ABD<sub>T002</sub>, ABD<sub>T004</sub>, ABD<sub>HT014</sub>, ABD<sub>HT015</sub> and ABD<sub>HT016</sub> binding to HSA and TNF-α. Kinetic constants from SPR-measurements were determined in triplicates on two different sensor chips on two different days and K<sub>D</sub> was calculated from the mean values of the rate constants. Standard deviations are shown and all parameters for TNF-α are calculated from the concentration of monomeric protein.</p
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