<p>The same dLGN morphology (<b>A</b>) was used in all simulations. The steady state values of activation/inactivation variables (red/black full lines), along with the activation/inactivation time constants (red/black dotted lines) are plotted as a function of voltage for voltage dependent ion channels (<b>B–F</b>), and as a function of intracellular calcium concentration for calcium dependent ion channels (<b>G–H</b>). <i>Na</i> and <i>K<sub>dr</sub></i> kinetics are shown for the parameterization P1 of the model. With respect to this, P2 kinetics was shifted +2.3 mV and +3.2 mV for <i>Na</i> and <i>K<sub>dr</sub></i> respectively. For all other ion channels, the same kinetics applies to both parameterizations (P1 and P2).</p
Direct G protein inhibition of N-type calcium channels is recognized by characteristic biophysical m...
Markov models of ion channel dynamics have evolved as experimental advances have improved our unders...
Since the first Hodgkin and Huxley ion channel model was described in the 1950s, there has been an e...
<p><i>ρ</i> represents the postulated number of gates, <i>m</i><sub>∞</sub> is the steady-state acti...
The linear, nonlinear and improved nonlinear thermodynamic models of the voltage-dependent ion chann...
We study the models for calcium (Ca) dynamics developed in earlier studies, in each of which the key...
We previously formulated dynamics of ion channel gates by the path probability method. In this study...
The ability of Ca ions to inhibit Ca channels presents one of the most intriguing problems in membra...
In this work, we propose a methodology based on Monte Carlo Markov chains to explore the parameter s...
Models of ion channel dynamics are usually built by fitting isolated cell experimental values of ind...
<p>(<b>A</b>) Representative L-type calcium ion-channel current (output) elicited by voltage steps f...
Ion channels are pores formed by proteins and responsible for carrying ion fluxes through cellular m...
In this study, we propose a theoretical framework for the determination of rate kinetics in the ion ...
AbstractVoltage-gated sodium channels play an important role in action potentials. If enough channel...
<p>A–C. The maximal value of Na<sup>+</sup> activation time constant τ<sub>m</sub> (A) and Na<sup>+<...
Direct G protein inhibition of N-type calcium channels is recognized by characteristic biophysical m...
Markov models of ion channel dynamics have evolved as experimental advances have improved our unders...
Since the first Hodgkin and Huxley ion channel model was described in the 1950s, there has been an e...
<p><i>ρ</i> represents the postulated number of gates, <i>m</i><sub>∞</sub> is the steady-state acti...
The linear, nonlinear and improved nonlinear thermodynamic models of the voltage-dependent ion chann...
We study the models for calcium (Ca) dynamics developed in earlier studies, in each of which the key...
We previously formulated dynamics of ion channel gates by the path probability method. In this study...
The ability of Ca ions to inhibit Ca channels presents one of the most intriguing problems in membra...
In this work, we propose a methodology based on Monte Carlo Markov chains to explore the parameter s...
Models of ion channel dynamics are usually built by fitting isolated cell experimental values of ind...
<p>(<b>A</b>) Representative L-type calcium ion-channel current (output) elicited by voltage steps f...
Ion channels are pores formed by proteins and responsible for carrying ion fluxes through cellular m...
In this study, we propose a theoretical framework for the determination of rate kinetics in the ion ...
AbstractVoltage-gated sodium channels play an important role in action potentials. If enough channel...
<p>A–C. The maximal value of Na<sup>+</sup> activation time constant τ<sub>m</sub> (A) and Na<sup>+<...
Direct G protein inhibition of N-type calcium channels is recognized by characteristic biophysical m...
Markov models of ion channel dynamics have evolved as experimental advances have improved our unders...
Since the first Hodgkin and Huxley ion channel model was described in the 1950s, there has been an e...