<p>TNF-α message levels were measured in colonic tissue following TNBS administration (0.3 mg) for 24 hrs in LITAF mac -/- mice (N = 6) and C57BL/6 mice (N = 12). Data are expressed as % Non-Inflamed control ± SEM. * Statistical difference (p<0.05).</p
a<p>In two independent studies, serum concentrations of 23 cytokines were determined by multiplex te...
<p>Colonic mucosal injury (0–3) and inflammation (0–3) scores were assessed in a blinded manner by a...
Icited macrophages (MΦ) (n = 3) 24 hrs after exposure to LPS. The IC50 threshold (the concentration ...
<p><b><i>A</i></b>) Following TNBS administration, LPM were harvested and stimulated with LPS (1 ug/...
<p><b><i>A</i></b>) Representative histological images of colonic inflammation: Untreated Control; T...
<p><b><i>A</i></b>) Secreted TNF-α from LPM harvested from inflamed colonic tissue are reduced when ...
<p><b><i>A</i></b>) Western blot of LITAF and Actin confirming the knockout of LITAF protein in peri...
<p>Inflammation was induced by TNBS (1.5 mg, in 50% ethanol solution) and animals were monitored for...
Ction, mice were challenged i.p. with a lethal dose of 0.5 mg LPS then euthanized 2 hrs. later for m...
Dysregulation of TNF-a in lamina propria macrophages (LPM) is a feature of inflammatory bowel diseas...
<p>TNF-α release (pg/ml) into the supernatant of organic colon culture from normal mice, following t...
<p>Colitis was induced in Ly49E WT and Ly49E KO mice by intra-rectal administration of TNBS. Mice we...
Treatment with i.p. (panel A) or oral (panel C) LMP-420 at the indicated doses. LMP-420 doses of 5 m...
<p>Representative photomicrographs of the colons of TNBS treated <i>Tnf-/-</i> (A) and WT mice (B) a...
Mice were treated with 2 ip injections of either P28GST or methylprednisolone after TNBS-injection. ...
a<p>In two independent studies, serum concentrations of 23 cytokines were determined by multiplex te...
<p>Colonic mucosal injury (0–3) and inflammation (0–3) scores were assessed in a blinded manner by a...
Icited macrophages (MΦ) (n = 3) 24 hrs after exposure to LPS. The IC50 threshold (the concentration ...
<p><b><i>A</i></b>) Following TNBS administration, LPM were harvested and stimulated with LPS (1 ug/...
<p><b><i>A</i></b>) Representative histological images of colonic inflammation: Untreated Control; T...
<p><b><i>A</i></b>) Secreted TNF-α from LPM harvested from inflamed colonic tissue are reduced when ...
<p><b><i>A</i></b>) Western blot of LITAF and Actin confirming the knockout of LITAF protein in peri...
<p>Inflammation was induced by TNBS (1.5 mg, in 50% ethanol solution) and animals were monitored for...
Ction, mice were challenged i.p. with a lethal dose of 0.5 mg LPS then euthanized 2 hrs. later for m...
Dysregulation of TNF-a in lamina propria macrophages (LPM) is a feature of inflammatory bowel diseas...
<p>TNF-α release (pg/ml) into the supernatant of organic colon culture from normal mice, following t...
<p>Colitis was induced in Ly49E WT and Ly49E KO mice by intra-rectal administration of TNBS. Mice we...
Treatment with i.p. (panel A) or oral (panel C) LMP-420 at the indicated doses. LMP-420 doses of 5 m...
<p>Representative photomicrographs of the colons of TNBS treated <i>Tnf-/-</i> (A) and WT mice (B) a...
Mice were treated with 2 ip injections of either P28GST or methylprednisolone after TNBS-injection. ...
a<p>In two independent studies, serum concentrations of 23 cytokines were determined by multiplex te...
<p>Colonic mucosal injury (0–3) and inflammation (0–3) scores were assessed in a blinded manner by a...
Icited macrophages (MΦ) (n = 3) 24 hrs after exposure to LPS. The IC50 threshold (the concentration ...