Spatial memory and exploratory and anxiety-like behaviour on the hole-board test.

<p>Mean values ± SEM. (A) Chronic stress impaired reference memory in both genotypes, but the deficit was more dramatic in maLPA₁-null mice. (B) This differential impairment was related to memory consolidation rather than acquisition, although acquisition was also affected by stress. (C) Chronic stress did not impair working memory, but null groups performed worse on the first training day. (D) MaLPA₁-null mice spent more time in the periphery (thigmotaxis) throughout the testing procedure. Only WT mice showed hyperactivity (locomotion, head dipping) in response to stress. D: Training day. Post-hoc LSD tests: (*<i>p</i><.05; **<i>p</i><.001): significant difference between the stressed group vs. its control; (#<i>p</i><.05; ##<i>p</i><.001): significant difference between the control NULL vs. the control WT mice.