<p>In Gα<sub>i2</sub><sup>−/−</sup> cardiomyocytes V<sub>0.5</sub> of the steady-state inactivation is significantly shifted to more negative potentials. In addition, Boltzmann fits revealed a significant flattening of the curves as indicated by increased slope factors.</p><p>*p<0.05 vs. WT,</p>†<p>p<0.05 vs. Gα<sub>i3</sub><sup>−/−</sup>.</p
<p>For the compound outward current in male and female wild-type (KChIP2<sup>+/+</sup>) myocytes the...
<p>A: Voltage dependence of steady-state fast inactivation as determined with the indicated pulse pr...
<p>Effect of exendin-4 treatment on Boltzmann parameters of activation and inactivation curves for I...
<p>A) Isochronal one second inactivation relationship “i”. Mean data points (n = 13) fit to a single...
<p>*p<0.05 vs WT;</p>#<p>p<0.05 vs control WT;</p>†<p>p<0.05 vs control CPVT.</p
<p>(A) Average peak currents normalized to cell capacitance. Smooth curves represent fits to the ave...
<p>(<b>A</b> and <b>B</b>) Normalized steady-state activation (A) and inactivation curves (B) of WT,...
<p>The voltage dependence of inactivation was studied in male myocytes with a variable prepulse prot...
<p>A. Data points and theoretical fit (solid lines, Eq. 3, Methods) for the steady-state inactivatio...
<p>The activation and inactivation gating variables for each of the 7 active membrane conductances u...
<p><b>a</b>, Typical examples of AP upstrokes (top) and their dV/dt's (bottom). <b>b</b>, Current-vo...
<p>Whole-cell patch-clamp recordings were taken from individual murine cardiomyocytes isolated from ...
<p>Activation and steady-state inactivation parameters were calculated by data fitting to Boltzmann ...
<p>Steady-state inactivation parameters of Ca<sub>V</sub>3.3, Ca<sub>V</sub>1.2 and chimeric channel...
<p>Recovery from inactivation and the voltage dependence of inactivation were studied in female KChI...
<p>For the compound outward current in male and female wild-type (KChIP2<sup>+/+</sup>) myocytes the...
<p>A: Voltage dependence of steady-state fast inactivation as determined with the indicated pulse pr...
<p>Effect of exendin-4 treatment on Boltzmann parameters of activation and inactivation curves for I...
<p>A) Isochronal one second inactivation relationship “i”. Mean data points (n = 13) fit to a single...
<p>*p<0.05 vs WT;</p>#<p>p<0.05 vs control WT;</p>†<p>p<0.05 vs control CPVT.</p
<p>(A) Average peak currents normalized to cell capacitance. Smooth curves represent fits to the ave...
<p>(<b>A</b> and <b>B</b>) Normalized steady-state activation (A) and inactivation curves (B) of WT,...
<p>The voltage dependence of inactivation was studied in male myocytes with a variable prepulse prot...
<p>A. Data points and theoretical fit (solid lines, Eq. 3, Methods) for the steady-state inactivatio...
<p>The activation and inactivation gating variables for each of the 7 active membrane conductances u...
<p><b>a</b>, Typical examples of AP upstrokes (top) and their dV/dt's (bottom). <b>b</b>, Current-vo...
<p>Whole-cell patch-clamp recordings were taken from individual murine cardiomyocytes isolated from ...
<p>Activation and steady-state inactivation parameters were calculated by data fitting to Boltzmann ...
<p>Steady-state inactivation parameters of Ca<sub>V</sub>3.3, Ca<sub>V</sub>1.2 and chimeric channel...
<p>Recovery from inactivation and the voltage dependence of inactivation were studied in female KChI...
<p>For the compound outward current in male and female wild-type (KChIP2<sup>+/+</sup>) myocytes the...
<p>A: Voltage dependence of steady-state fast inactivation as determined with the indicated pulse pr...
<p>Effect of exendin-4 treatment on Boltzmann parameters of activation and inactivation curves for I...