Dynamics of vascular network formation.

<p>(A) Detail of simulated tissue at various time points, showing the cells (top) and relative concentrations of bound VEGF with isolines (bottom). (B) Dynamics of number of isolated cellular structures (blue) and number of lacunae (red), half-transparent regions indicates standard deviation (n = 10). (C) Inset depicts remodeling in a small region. This occupancy map is constructed by averaging over binary images in the interval between 1000 and 2000 MCS; lines show cell boundaries at 2000 MCS. Grey/white pixels are cells/lacuna which remained unchanged over this period; colored pixels indicates how long a pixel has been occupied by cells. It shows the creation of new connections (arrows) increasing the number of lacunae.