Effect of maternal prenatal androgenization on adult liver lipid content and other metabolic parameters.

<p>A) Representative oil red O histological stains for lipids in ovine adult liver sections illustrating negative (-), possible early (+/−) or positive (+) fatty liver (scale bars = 50 µm) and B) analysis of control (C; n = 5) and maternal TP (n = 9) showing increased fatty liver in the TP cohort. Maternal prenatal TP treatment had no effect on adult liver analytes including aspartate transaminase (AST; C) and gamma glutamyltransferase (GGT; D). There was no effect on body weight (E), weight of omental fat (F), plasma leptin (G) and cholesterol levels (J). H) Plasma glucose concentrations at basal levels and 15 min after i.v. glucose bolus showed no differences, however, after 15 min there were significantly higher plasma insulin concentrations in the TP group (I). Values are mean ± SEM and * = <i>P</i><0.05.