CO6-MMP serum levels in CCl4-treated rats.

<p>CCl4 rat liver fibrosis model: (A) Serum CO6-MMP was assessed in control rats at termination (controls) as well as in CCl4-treated rats at termination (CCl4) at weeks 8, 12, 16, 20. Results shown are mean ± standard error of the mean (SEM); (B) Serum CO6-MMP in all controls pooled and CCl4 rat stratified in quartiles according to total collagen in the liver; (C) Correlations between CO6-MMP and Sirius red in (C) CCl4 rats and in (D) control rats; Asterisks indicate statistical significance as indicated by bars. (** = p<0.05; *** = p<0.001, ns = non-significant difference).