KNK437 abrogates the resistance to STS-induced apoptosis in SH-SY5Y and 5YHSP72.1 cells.

<p>SH-SY5Y cells (black bars) and 5YHSP72.1 (striped bars) were thermally preconditioned (PC) or not, 8 h before treatment with 50 nM STS for a further 12 h. Where indicated, KNK437 was added to undifferentiated SH-SY5Y cells (50 µM) or 5YHSP72.1 cells (75 µM) 1 h before thermal preconditioning. Quantified data are shown for nuclear fragmentation (A) and Bax activation (B). At least 300 cells were scored for each of three independent experiments; error bars indicate standard deviation. *<i>p</i>&lt;0.05; **<i>p</i>&lt;0.01; ***<i>p</i>&lt;0.0001.