IFG-1 p170 depletion induces apoptosis that requires the caspase and apoptosome.

<p>(A) Fluorescence images of Control (RNAi) and p170 (RNAi)-treated adults from wild type, <i>ced-3</i> (n2452) and <i>ced-4</i> (n1162) strains expressing the apoptotic marker CED-1::GFP. Worms were fed E. coli expressing the dsRNA corresponding to each RNAi target, and the gonads of young adult F1 offspring (similarly fed) were analyzed by fluorescence microscopy. White arrows indicate GFP positive apoptotic germ cell corpses. (B) Bar graph depicting quantitative comparison of germ cell apoptosis induced by <i>ifg-1</i> p170 mRNA depletion based on number of GFP-decorated corpses per lobe of the gonad. ‘n’ refers to number of adult gonad lobes in which corpses were counted. Error bars display S.E.M.