Hippocampal HIF-1α, c-Fos, and pMAPK expression increased gradually with increasing numbers of post-ischemia IH interventions.

<p>(A) Experimental design. Ischemic rats were exposed to differing numbers (1, 3, 5, or 7) of IH interventions or sham IH sessions. (B) Immunoblotting was used to detect hippocampal HIF-1α, pMAPK, MAPK, and c-Fos expression. (C–E) Quantification of immunoblotting results. *<i>p</i><0.05, **<i>p</i><0.01, compared to the MCAOIH ×7 group. †<i>p<</i>0.05, ††<i>p<</i>0.01, compared to the MCAO group.