Prolongation of survival of passively immunized mice following challenge with wild-type H5N1 virus.

<p>Groups of 7 or 10 CD1 mice received immune sera from (<b>A</b>) CD1 mice, (<b>B</b>) guinea pigs or (<b>C</b>) humans and survival was monitored for 14 days. Shown are the mean % of surviving animals each day following lethal challenge. Reciprocal neutralizing antibody titers shown are the means extrapolated from titers measured immediately prior to challenge. N = Naive serum. All mice receiving mouse immune sera of mean titer ≥1∶16 and guinea pig immune sera of mean titer ≥ 1∶43 were protected.