Effect of cytokines on inward Na⁺ exchange via NCX in human ASM.

<p>In SBFI loaded ASM cells where this mode of NCX was evaluated using the protocol illustrated in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0023662#pone-0023662-g007" target="_blank">Figure 7</a>, TNFα or IL-13 significantly enhanced inward Na⁺ exchange, while KBR7943 and NCX1 siRNA (but not negative siRNA) both significantly inhibited inward Na⁺ exchange. Values are means ± SE (n = 5 patient samples for controls, 3 patient samples for cytokine groups; minimum 50 cells per bar). % indicates significant KBR7943 effect, * significant NCX1 siRNA effect, and # significant cytokine effect (p<0.05).