Development, growth, and survival of TMPRSS11A- and HAT-deficient mice.

<p>A and B. Genotype distribution of weaning-age offspring of interbred <i>Tmprss11a^+/−</i> (A) and <i>Tmprss11d^+/−</i> (B) mice. C–F. Post-weaning weight gain of cohorts of littermate <i>Tmprss11a^+/+</i> (golden triangles, N = 16), <i>Tmprss11a^+/−</i> (black squares, N = 15), and <i>Tmprss11a^−/−</i> (red triangles, N = 15) females (C), <i>Tmprss11a^+/+</i> (golden triangles, N = 15), <i>Tmprss11a^+/−</i> (black squares, N = 15), and <i>Tmprss11a^−/−</i> (red triangles, N = 15) males (E), <i>Tmprss11d^+/+</i> (golden triangles, N = 12), <i>Tmprss11d^+/−</i> (black squares, N = 15), and <i>Tmprss11d^−/−</i> (red triangles, N = 6) females (D), <i>Tmprss11d^+/+</i> (golden triangles, N = 15), <i>Tmprss11d^+/−</i> (black squares, N = 15), and <i>Tmprss11d^−/−</i> (red triangles, N = 7) males (F). G and H. Survival of prospective cohorts of littermate <i>Tmprss11a^+/+</i> (golden lines, N = 30), <i>Tmprss11a^+/−</i> (black lines, N = 30), and <i>Tmprss11a^−/−</i> (red lines, N = 30) mice (G) and <i>Tmprss11d^+/+</i> (golden lines, N = 27), <i>Tmprss11a^+/−</i> (black lines, N = 30), and <i>Tmprss11a^−/−</i> (red lines, N = 13) (H) mice that were followed for at least 500 days.