GABA-dependent mechanism for enlarged b-wave.

<p>Light leads to a decrease in glutamate (glu) in the cone synaptic cleft. This causes depolarization and release of glutamate from ON-bipolar cells (ON-BC) and consequent GABA release from amacrine cells (AC). The b-wave is a circulation of current around the ON-bipolar cell that is generated, in part, from Na⁺ ions flowing into dendrites and chloride ions (Cl⁻) flowing through GABA receptors into terminals. An increase in GABA receptor number in <i>celsr3</i> mutants would increase this current loop, resulting in an enlarged b-wave response.