<p>a. Body length of the wild type larvae and those co-injected with prGC3N/p5BR. b. Phenotype of wild type larvae and those co-injected with prGC3N/p5BR. The scales represent 500 um. c. Expression of the HCV-associated genes in zebrafish larvae. The mRNA level of the study genes were examined with RT-PCR reaction in wild-type and the prGC3N/p5BR co-injection larvae (8 dpf and 12 dpf).</p
<p>(A) Top left: Macroscopic views of zebrafish in Group 1. Red arrow indicates a distended abdomen....
<p>(<b>A-C</b>) Control 4-month-old zebrafish showing the liver (L, outlined) positioned in the body...
<p>(A) Scheme of a 72 hours post-fertilization (hpf) larva, showing the site of injection in the dor...
<p>a. The HCV sub-replicon was created with prGC3N and p5BR vectors. Cartoons are for vector prGC3N,...
<p>RT-PCR was used to assess the gene expression in pFL-GIC- and pFL-G-injected larvae and in WT lar...
<p>Zebrafish larvae co-injected with prGC3N/p5BR were treated with ribavirin or oxymatrine respectiv...
Screening and evaluating anti- hepatitis C virus (HCV) drugs in vivo is difficult worldwide, mainly ...
<p>A. Transcription level of core and gfp in pFL-GIC injected zebrafish larvae at 3-, 6- and 9-dpf w...
<p>RT-PCR (upper panel) and Western blotting (lower panel) were used for detecting expression of cor...
<p>Whole mount <i>in situ</i> hybridization was carried out on 8-dpf larvae using antisense or sense...
<p>A. Diagrams of plasmid constructs. In pFL-GIC the core cds and GFP cds are driven by L-FABP enhan...
Zebrafish larvae were micro-injected with on average 143 ± 76 CFU of wildtype B. cenocepacia K56-2 (...
<p>A) Quantitative RT-PCR results revealed fold changes in the expression levels of <i>Cav-1b</i> in...
<p>(A) As measured by QGP, the genes for which expression is affected by 3h exposure to tBHP (800 μM...
<p>Values represent mean ± SEM (n = 6 samples; each sample included 30 larvae). Significant differen...
<p>(A) Top left: Macroscopic views of zebrafish in Group 1. Red arrow indicates a distended abdomen....
<p>(<b>A-C</b>) Control 4-month-old zebrafish showing the liver (L, outlined) positioned in the body...
<p>(A) Scheme of a 72 hours post-fertilization (hpf) larva, showing the site of injection in the dor...
<p>a. The HCV sub-replicon was created with prGC3N and p5BR vectors. Cartoons are for vector prGC3N,...
<p>RT-PCR was used to assess the gene expression in pFL-GIC- and pFL-G-injected larvae and in WT lar...
<p>Zebrafish larvae co-injected with prGC3N/p5BR were treated with ribavirin or oxymatrine respectiv...
Screening and evaluating anti- hepatitis C virus (HCV) drugs in vivo is difficult worldwide, mainly ...
<p>A. Transcription level of core and gfp in pFL-GIC injected zebrafish larvae at 3-, 6- and 9-dpf w...
<p>RT-PCR (upper panel) and Western blotting (lower panel) were used for detecting expression of cor...
<p>Whole mount <i>in situ</i> hybridization was carried out on 8-dpf larvae using antisense or sense...
<p>A. Diagrams of plasmid constructs. In pFL-GIC the core cds and GFP cds are driven by L-FABP enhan...
Zebrafish larvae were micro-injected with on average 143 ± 76 CFU of wildtype B. cenocepacia K56-2 (...
<p>A) Quantitative RT-PCR results revealed fold changes in the expression levels of <i>Cav-1b</i> in...
<p>(A) As measured by QGP, the genes for which expression is affected by 3h exposure to tBHP (800 μM...
<p>Values represent mean ± SEM (n = 6 samples; each sample included 30 larvae). Significant differen...
<p>(A) Top left: Macroscopic views of zebrafish in Group 1. Red arrow indicates a distended abdomen....
<p>(<b>A-C</b>) Control 4-month-old zebrafish showing the liver (L, outlined) positioned in the body...
<p>(A) Scheme of a 72 hours post-fertilization (hpf) larva, showing the site of injection in the dor...