BBB opening in V3.

<p>A 3D Spoiled Gradient-Echo (SPGR) T1-weighted sequence was applied after intravenous (IV) injection of gadodiamide 1 h after sonication. Gadodiamide presence in the brain parenchyma is induced by BBB opening. (<b>A</b>) Coronal MR images confirming the local disruption of the BBB, two opening sites are circled confirmed by the diffusion of the contrast agent (purple circle 0.3 MPa and orange circle 0.45 MPa). (<b>B</b>) Coronal MR images 6 days, after sonication, confirming closing of the BBB and proving reversibility of the procedure. (<b>C</b>,<b>D</b>) Sagittal MR images of the two sonication sites at two different pressures 0.3 MPa (<b>C</b>) and 0.45 MPa (<b>D</b>). (<b>E</b>,<b>F</b>) Magnification of the corresponding color boxes.