Identification of TgPKA-R.

<p><b>A</b>, Schematic linear domain structure of a mammalian PKA-R. The N-terminal dimerization domain, inhibitory site, cAMP-binding domain A, and cAMP-binding domain B are shown. <b>B</b>, Comparison of predicted TgPKA-R amino acid sequences (ToxoDB identifier: TGGT1_048350) with those of <i>P. falciparum</i> PKA-R (PfPKA-R, GenBank Accession Number: AJ441326) and <i>H. sapiens</i> PKA-R isoforms Iα (HsPKA-RIα, GenBank Accession Number: NP_002725), Iβ (GenBank Accession Number: NP_001158230), IIα (GenBank Accession Number: NP_004148), and IIβ (GenBank Accession Number: NP_002727). Amino acid identity (black boxes) and similarity (gray boxes) are shown within the protein kinase domain. Gaps introduced to optimize alignments are marked by dashes. The conserved phosphate-binding cassettes of cAMP-binding domains A (PBC-A) and B (PBC-B) are shown with a solid line, and the inhibitory sequence is indicated by a dotted line. The phosphorylable serine is indicated by a black arrow.