δPKC translocates to the mitochondria following CA and δPKC activation following OGD increases cytochrome <i>c</i> release.

<p>A) Immunoblot of δPKC in hippocampal mitochondria of a rat subjected to 8 min of CA and 1 h of reperfusion. Levels of δPKC normalized against COXIV for loading control are expressed as percentage from sham-operated (control) group. B) Immunoblots of δPKC in mitochondria isolated from hippocampal synaptosomes without ischemia or following 1 h oxygen glucose deprivation (OGD) in presence of tat (control) or δPKC inhibitor (δV1-1). Levels of δPKC normalized against COXIV for loading control are expressed as percentage of control δPKC protein expression. C) Immunoblot of cytochrome <i>c</i> in the soluble fraction of hippocampal synaptosomes subjected to oxygen glucose deprivation (OGD) in the presence of tat, δV1-1 or okadaic acid. Levels of cytochrome <i>c</i> normalized against β-actin for loading control are expressed as percentage of OGD in the presence of tat (control) group. *, <i>p</i><0.05 v. sham or tat treated group.