<p>Mice were sensitized and challenged as described in Methods. Serum levels of immunoglobulins were assessed 48 h after the last challenge. Mean values±SEM are given. <i>Il22<sup>−/−</sup></i>: C57Bl/6 IL-22 deficient mice, <i>Il22<sup>+/+</sup></i>: congenic wild-type control mice. N.D.: not detectable.</p><p>#p<0.05 compared to <i>Il22<sup>+/+</sup></i>chall and <i>Il22<sup>−/−</sup></i> chall.</p
<p>A. ELISA assay to measure immunoglobulin isotypes in the sera of control and mutant mice. Sera an...
<p>The levels of IFN-γ IL-2, IL-4, and IL-5 were determined in individual sera (n = 10 mice/group) b...
<p>(A) Resting antibody levels in serum from ten-week-old WT and IL-7Rα<sup>449F/449F</sup> mice. (B...
<p>Airway resistance (panel A) and dynamic compliance (panel B) in challenged only wild-type (IL-22<...
<p>Experimental design was the same as for <a href="http://www.plosone.org/article/info:doi/10.1371/...
<p><b>A:</b> 16 female B6.129S7-ifng<sup>tm1Ts</sup> (B6.IFNγKO) mice were immunized with collagen a...
<p>Wild-type and <i>Il22</i><sup>-/-</sup> mice were intradermally infected with 2 x10<sup>6</sup><i...
<p>On days 6 and 12, IL-22 mRNA was measured by real-time RT-PCR from ears of WT PBS-injected or WT ...
<p><b>A:</b> DBA mice were immunized with collagen and CFA. Splenocytes (5×10<sup>6</sup>/ml) from n...
<p><b>A.</b> 16 DBA mice were immunized with collagen and CFA. Mice with total score ≥1 and arthriti...
<p>(<b>A</b>) Serum IgM and IgG levels of 4 and 12 mo-old WT, CD22<sup>−/−</sup>, CD154<sup>TG</sup>...
<p>Wild-type (WT; gray bars) and IL-22<sup>-/-</sup> (black bars) mice were infected with 5 <i>H</i>...
<p>BAL of control and sensitized mice was collected 24 h after the last challenge with PBS or SGE, a...
On the 7th day of the experiment, mice were sacrificed to separate serum, and the levels of cytokine...
<div><p>(A–C) Serum from mice that received T cells 8 d before were assayed for total immunoglobulin...
<p>A. ELISA assay to measure immunoglobulin isotypes in the sera of control and mutant mice. Sera an...
<p>The levels of IFN-γ IL-2, IL-4, and IL-5 were determined in individual sera (n = 10 mice/group) b...
<p>(A) Resting antibody levels in serum from ten-week-old WT and IL-7Rα<sup>449F/449F</sup> mice. (B...
<p>Airway resistance (panel A) and dynamic compliance (panel B) in challenged only wild-type (IL-22<...
<p>Experimental design was the same as for <a href="http://www.plosone.org/article/info:doi/10.1371/...
<p><b>A:</b> 16 female B6.129S7-ifng<sup>tm1Ts</sup> (B6.IFNγKO) mice were immunized with collagen a...
<p>Wild-type and <i>Il22</i><sup>-/-</sup> mice were intradermally infected with 2 x10<sup>6</sup><i...
<p>On days 6 and 12, IL-22 mRNA was measured by real-time RT-PCR from ears of WT PBS-injected or WT ...
<p><b>A:</b> DBA mice were immunized with collagen and CFA. Splenocytes (5×10<sup>6</sup>/ml) from n...
<p><b>A.</b> 16 DBA mice were immunized with collagen and CFA. Mice with total score ≥1 and arthriti...
<p>(<b>A</b>) Serum IgM and IgG levels of 4 and 12 mo-old WT, CD22<sup>−/−</sup>, CD154<sup>TG</sup>...
<p>Wild-type (WT; gray bars) and IL-22<sup>-/-</sup> (black bars) mice were infected with 5 <i>H</i>...
<p>BAL of control and sensitized mice was collected 24 h after the last challenge with PBS or SGE, a...
On the 7th day of the experiment, mice were sacrificed to separate serum, and the levels of cytokine...
<div><p>(A–C) Serum from mice that received T cells 8 d before were assayed for total immunoglobulin...
<p>A. ELISA assay to measure immunoglobulin isotypes in the sera of control and mutant mice. Sera an...
<p>The levels of IFN-γ IL-2, IL-4, and IL-5 were determined in individual sera (n = 10 mice/group) b...
<p>(A) Resting antibody levels in serum from ten-week-old WT and IL-7Rα<sup>449F/449F</sup> mice. (B...