Inducible genetic targeting of Cdc42 inhibited platelet spreading on immobilized CRP and fibrinogen.
- Huzoor Akbar (340517)
- Xun Shang (348052)
- Rehana Perveen (340511)
- Mark Berryman (348053)
- Kevin Funk (340512)
- James F. Johnson (348054)
- Narendra N. Tandon (348055)
- Yi Zheng (113896)
Publication date
February 2013
DOIAbstract
<p>Spreading of washed platelets from Cdc42<sup>+/+</sup> and Cdc42<sup>−/−</sup> mice on CRP or fibrinogen was quantified using Image J software (<a href="http://rsbweb.nih.gov/ij" target="_blank">http://rsbweb.nih.gov/ij</a>). Each bar represents mean surface are ± SEM of 100 platelets. The spreading of Cdc42<sup>−/−</sup> platelets on immobilized CRP or fibrinogen was significantly (p<0.01) diminished as compared to the Cdc42<sup>+/+</sup> platelets.</p
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