Genetic targeting of Cdc42 inhibited release of p-selectin from α-granules and secretion of ATP from dense granules.

<p>A, Thrombin (0.2 U/ml) induced expression of P-selectin and B, CRP (0.2 µg/ml) induced secretion of ATP is inhibited in platelets from Cdc42^−/− mice compared with the platelets from Cdc42^+/+ mice. Bar graphs are the means ± SD (n = 3).