Schematic domain structure of full-length VWF and recombinant VWF fragments.
- Jingyu Zhang (256203)
- Zhenni Ma (328280)
- Ningzheng Dong (328283)
- Fang Liu (13271)
- Jian Su (86223)
- Yiming Zhao (348349)
- Fei Shen (348351)
- Anyou Wang (281729)
- Changgeng Ruan (328282)
Publication date
February 2013
DOIAbstract
<p>The domain structure of human preproVWF is shown above the structures of recombinant VWF fragments designed in this study. ADAMTS-13 cleaves the Y1605-M1606 peptidyl bond in the A2 domain (D1459-L1668). Five different recombinant VWF domains with His-tags (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0022157#pone-0022157-g005" target="_blank">Figure 5A</a>) and 5 different recombinant proteins derived from the VWF A2 domain flanked with GST- and His-tags (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0022157#pone-0022157-g005" target="_blank">Figure 5B</a>).</p
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