Effect of donepezil on MMP-9 in macrophages.

<p>MMP-9 in culture medium was evaluated by Western blot analysis before and after LPS (10 ng/ml) treatment with or without donepezil pretreatment (100 µM). Compared to control (control), LPS treatment significantly increased MMP-9 in culture medium (LPS), whereas donepezil pretreatment significantly decreased MMP-9 even in the presence of LPS (DPZ/LPS). #, <i>P<0.01</i>.