Changing subtype content during development improves calcium potentiation during paired stimulations.

<p>(A) Spike time dependent plasticity (STDP) was simulated by pairing presynaptic glutamate release with postsynaptic depolarization at different time intervals. (B) Calcium influx was greatest in the mature subtype content and was increased by paired stimulation when pre and post spikes were given simultaneously (Δt = 0). (C) The variance in the fold increase of calcium influx generated by paired depolarization was greatest for young cultures, again demonstrating that NR2A content significantly improves the extent and reliability of signaling during this model of plasticity (* p<0.05 compared to other distributions).