The predicted distribution of host susceptibility.

<p>The distribution of host susceptibility predicted by model 2 with fitted parameters: <i>p</i> = 0.0059, <i>α</i> = 0.335, <i>β</i> = 143 (<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1002097#pcbi-1002097-t003" target="_blank">Table 3</a>). Host susceptibility is characterized by the overall probability of disease causation for a single ODV, <i>pξ</i>, which is the product of the <i>per virion</i> chances of successful penetration, <i>p</i>, and the probability of successful infection given successful penetration, <i>ξ</i>. The shape of the cumulative distribution of <i>pξ</i> is the same as that of the beta distribution for <i>ξ</i>, but the domain of the former is limited to (0, <i>p</i>], and the distribution is accordingly shifted to the left compared to the beta distribution for <i>ξ w</i>hich has (0,1] as its domain. A logarithmic scale is used for the abscissa to represent the broad range of susceptibility in the host population, which is reflected in shallow dose response and is – as shown in this paper – intrinsically associated with a high incidence of mixed genotypes in cadavers.