ICER, CART, and Pdyn mRNA levels in the CPu after single and repeated METH treatment.

<p>The mice were administered METH (1 mg/kg, i.p.) or saline once or received METH (1 mg/kg, i.p.) once every other day from Day 1 to Day 13 and challenged with saline or METH (1 mg/kg, i.p.) on Day 20 after a 7 day drug-free period. The mice were decapitated 1 h after the last METH or saline treatment. <i>a</i>. ICER mRNA expression in the CPu in wildtype (WT) and ICER I-overexpressing (Tg) mice. The data are expressed as mean ± SEM (<i>n</i> = 4). <i>b</i>. CART mRNA expression in the CPu after single and repeated METH treatment. The data are expressed as mean ± SEM (<i>n</i> = 4). <i>c</i>. Pdyn mRNA expression in the CPu after single and repeated METH treatment. The data are expressed as mean ± SEM (<i>n</i> = 4).