Simvastatin reduced 6-OHDA medicated elevations of NMDANR1 receptors, TNF-a, and MMP9.

<p>6-OHDA incubation pronouncedly increased the NR1 receptors compared with controls (***p<0.001, 6-OHDA <i>vs</i> controls, n = 6–9); while this elevation was significantly abolished following simvastatin treatment (†††p<0.001, 6-OHDA <i>vs</i> 6-OHDA+sim, n = 6–9). Compared with controls, 6-OHDA produced significant increases in the total amount of TNF-a and MMP9 (***p<0.001, 6-OHDA <i>vs</i> controls, n = 6–9); while these increases were prevented by simvastatin treatment (†††p<0.001, 6-OHDA <i>vs</i> 6-OHDA + sim, n = 6–9). All the results are expressed as mean ± standard error of the mean.