<p>Tissue sections of lymphoid organs (spleen, lymph node, and thymus) from humanized Rag1<sup>−/−</sup>γc<sup>−/−</sup> mice were stained for the presence of human leukocytes. CD45<sup>+</sup> leukocytes (A,B,C), CD68<sup>+</sup> macrophages/dendritic cells (D,E,F), CD3<sup>+</sup> T cells (G,H,I), CD4<sup>+</sup> helper T cells (J,K,L), CD8<sup>+</sup> cytotoxic T cells (M,N,O) and CD20<sup>+</sup> B cells (P,Q,R) were detected in each of the organs assayed.</p
<p>(A) Infected footpad (3×10<sup>6 </sup><i>L. major</i>) of a humanized mouse is shown. (B) The in...
<p>Frequency of human leukocytes (hCD45<sup>+</sup>) measured by FACS in the blood of (a) HIS and (B...
Immunodeficient NOD.Cg-Prkdcscid Il2rgtm1Wjl/ SzJ (NSG) mice are a valuable resource to study human ...
<p>Single cell suspensions were made from spleen, bone marrow, lymph node and thymus of humanized Ra...
<p>The (A) percentage and (B) total number of hCD45<sup>+</sup> cells in the bone marrow (BM), thymu...
<p>Cells of hematopoietic origin in lymphoid organs and bone marrow were analyzed by flow cytometry....
<p>(A) Representative FACS profile of human CCR5<sup>+</sup>CD4<sup>+</sup> and CXCR4<sup>+</sup>CD4...
<p>The oral mucosa, salivary glands, CLN and NALT were harvested from BLT mice and stained with the ...
<p>Peripheral blood, spleen, lymph nodes, and bone marrow were harvested at GvHD development in Hu-P...
<p>Human B2M<sup>+</sup> cells (green) are seen growing as colonies in the parenchyma (top row). The...
The human immune system is comprised of about 2 X 10 lymphocytes containing approximately equal rati...
Immunotoxicology has developed into an integral regulatory requirement of the toxicological assessme...
<p>Representative FACS contour plots of liver-isolated cells from HIS-HUHEP mice are shown for each ...
<p>(A) Representative immunohistochemistry staining of CD4 from the kidneys of A<sub>2A</sub>R KO an...
Laboratory models enabling to study in vivo human leukocyte functions have been developed. Most of t...
<p>(A) Infected footpad (3×10<sup>6 </sup><i>L. major</i>) of a humanized mouse is shown. (B) The in...
<p>Frequency of human leukocytes (hCD45<sup>+</sup>) measured by FACS in the blood of (a) HIS and (B...
Immunodeficient NOD.Cg-Prkdcscid Il2rgtm1Wjl/ SzJ (NSG) mice are a valuable resource to study human ...
<p>Single cell suspensions were made from spleen, bone marrow, lymph node and thymus of humanized Ra...
<p>The (A) percentage and (B) total number of hCD45<sup>+</sup> cells in the bone marrow (BM), thymu...
<p>Cells of hematopoietic origin in lymphoid organs and bone marrow were analyzed by flow cytometry....
<p>(A) Representative FACS profile of human CCR5<sup>+</sup>CD4<sup>+</sup> and CXCR4<sup>+</sup>CD4...
<p>The oral mucosa, salivary glands, CLN and NALT were harvested from BLT mice and stained with the ...
<p>Peripheral blood, spleen, lymph nodes, and bone marrow were harvested at GvHD development in Hu-P...
<p>Human B2M<sup>+</sup> cells (green) are seen growing as colonies in the parenchyma (top row). The...
The human immune system is comprised of about 2 X 10 lymphocytes containing approximately equal rati...
Immunotoxicology has developed into an integral regulatory requirement of the toxicological assessme...
<p>Representative FACS contour plots of liver-isolated cells from HIS-HUHEP mice are shown for each ...
<p>(A) Representative immunohistochemistry staining of CD4 from the kidneys of A<sub>2A</sub>R KO an...
Laboratory models enabling to study in vivo human leukocyte functions have been developed. Most of t...
<p>(A) Infected footpad (3×10<sup>6 </sup><i>L. major</i>) of a humanized mouse is shown. (B) The in...
<p>Frequency of human leukocytes (hCD45<sup>+</sup>) measured by FACS in the blood of (a) HIS and (B...
Immunodeficient NOD.Cg-Prkdcscid Il2rgtm1Wjl/ SzJ (NSG) mice are a valuable resource to study human ...