Open field activity in the absence and presence of female urine in adult male <i>Shank1</i> mice.

<p>(A) Total number of rearings and (B) distance traveled during the 60 min habituation session to the clean open field without female urine displayed by male subjects before they had an experience of social interactions with a female, and 7 days after they had a 5 minute experience of social interactions with a female. (C) Total number of rearings and (D) distance traveled during the 5 min test session in the same open field containing urine from a female C57BL/6J mouse displayed by male subjects before they had an experience of social interactions with a female and after female experience. Black bar: <i>Shank1^+/+</i> wildtype littermate control mice; striped bar: <i>Shank1^+/</i>⁻ heterozygote mice; white bar: <i>Shank1</i>^{−<i>/</i>−} null mutant mice. Data are presented as means ± standard errors of the mean. * p<0.050 vs. <i>Shank1^+/+</i>; # p<0.050 vs. <i>Shank1^+/</i>⁻.