The glucose control by RSV is blunted in high fat diet-fed Glp1r^−/− mice.

<p><b>A)</b> Glycemic profiles (mg/dL) of high fat diet-fed Glp1r^−/− mice treated with vehicle (triangles) or RSV (squares) for five weeks and <b>B)</b> an index of area under the curve glucose (AUC); <b>C)</b> proglucagon mRNA levels (Relative expression level REL) of high fat diet-fed mice treated with vehicle (open bars) and RSV (closed bars) for five weeks. <b>D)</b> Glycemic profiles (mg/dL) of high fat diet-fed wild type mice (high fat diet-fed mice treated with vehicule (white triangles) or RSV (white squares)) and Glp1r^−/− mice (high fat diet-fed mice treated with vehicule (black triangles) or RSV (black squares)) after five weeks of treatment and <b>E)</b> an index of area under the curve glucose (AUC). Data are presented as mean ± S.E.M, n = 8 mice per group.