Long lasting anti-diabetic effects of PEGylated rhFGF21 in type 2 diabetic rats.

<p>Diabetic rat model and rhFGF21 treatment are same as <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0020669#pone-0020669-g005" target="_blank">Figure 5</a>. However, hypoglycemic (A) and hypolipidemic effects (B) as well as effect on plasma insulin levels (C) of native and PEGylated rhFGF21 were examined at different times [0 (1 h), 2 days, 4 days and 6 days] after the last treatment of the 7-day treatment with native or PEGylated rhFGF21 at the 4×10⁻⁸ mol/kg. Blank control: normal control rats; #, p<0.01 vs corresponding native rhFGF21 group; *, p<0.05 between indicated groups.