RA induces aneuploidy increase in pluripotent stem cells but not in somatic cells.
- Rafaela C. Sartore (350389)
- Priscila B. Campos (350390)
- Cleber A. Trujillo (350391)
- Bia L. Ramalho (350392)
- Priscilla D. Negraes (350393)
- Bruna S. Paulsen (191881)
- Tamara Meletti (232076)
- Elaine S. Costa (214335)
- Leonardo Chicaybam (350394)
- Martin H. Bonamino (350396)
- Henning Ulrich (184271)
- Stevens K. Rehen (191884)
Publication date
February 2013
DOIAbstract
<p>(A) Metaphase spreads of RA-NPCs derived from ES cells stained with DAPI. After RA-neural differentiation, the aneuploidy level increased in (B) ES and (C) iPS cells, while (D) mouse embryonic fibroblasts (MEF) exposed to RA did not present aneuploidy increase. The data refer to mean ± S.E.M. of three independent experiments, *p<0.05. ES, embryonic stem cells; iPS, induced pluripotent stem cells; NPCs, neural progenitor cells; RA, <i>all-trans</i> retinoic acid.</p
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