Degradation of α-actin is prevented by <i>asp-4</i> and <i>asp-6</i> RNAi in spaceflight and ground control (GC).

<p>Dauer animals treated for 4 d with RNAi vector control (VC) developed to adulthood. In both GC and spaceflight conditions animals displayed major loss of muscle specific α-actin following lysis in the absence of lysosomal protease inhibitors. Treatment with <i>asp-4</i> and <i>asp-6</i> RNAi for 4 d in GC and spaceflight resulted in a preservation of α-actin levels. A, representative immunoblot; B, average non-normalised quantification of three Western blots against α-actin. ** denotes significant difference from both GC and spaceflight VC conditions (<i>P</i><0.01).