Nicotinic acid promotes epidermal differentiation in photodamaged human skin.

<p>Tissue arrays of skin biopsy samples from a clinical study of the effects of myristyl nicotinate (MN) in human subjects with photodamaged skin <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0020487#pone.0020487-Jacobson1" target="_blank">[5]</a> were stained for the terminal differentiation markers caspase 14 and filaggrin. <b>Panel A:</b> An example of a biopsy sample at baseline and 12 weeks of MN treatment stained with H&E, and immunostaining for caspase 14 or filaggrin. <b>Panel B:</b> Quantification of staining for the placebo (n = 27) and MN treated (n = 31) groups for caspase 14 and filaggrin. Students t-test was used to compare placebo and MN treated groups and p values are shown.