Strong topological connectivity can suppress spiking activity in a network of neurons coupled by gap junctions.

<p><b>A</b> Network-averaged firing rate (meanS.E.M.) vs. the intensity of driving noise, for different scenarios of topological connectivity: Z = 4 connections per neuron (black closed squares); Z = 24 connections per neuron (red open circles). The firing rate was computed over the time window of 20 seconds. The coupling strength was . <b>B</b> Spike number disorder vs. the number of topological connections, for different driving noise intensities: (red); (black). <b>C</b> Sample raster plots of network activity, for different scenarios of topological connectivity and driving noise intensities: (left top); (left middle); (left bottom); (right top); (right middle); (right bottom).