Analysis of plasmid copy number control using growth-rate dependent parameters.

<p>(A) Growth-rate dependence of the number of RNA I molecules per plasmid (open circles) and the ratio of the transcription and degradation rates of RNA I (filled circles), normalized to their values at 1 doubling/hour (data from <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0020403#pone-0020403-t001" target="_blank">Table 1</a>). (B) Correlation between the plasmid copy number and the RNA I degradation rate at different growth rates for data from ref. <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0020403#pone.0020403-Jasiecki1" target="_blank">[26]</a>, values calculated from (A) are indicated by crosses. (C) Growth-rate dependence of the replication probability <i>R</i> as calculated from Eq. (1) using data from <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0020403#pone-0020403-t001" target="_blank">Table 1</a>. (D) Replication probability [as in (C)] at different growth rates plotted against the corresponding RNA I concentration for wild type and <i>rom</i>^- plasmids. The lines are fits with the multiple-steps mechanism.