Proportions of DPT cells in the blood and liver of chronically HCV- or HBV-infected, HCV-HIV co-infected and non-infected patients.

<p><b>A,</b> Representative dot plot of PBMCs labeled with the BD Multitest 6-Color TBNK Reagent: CD45⁺CD16⁻CD56⁻ CD19⁻CD3⁺ PBMCs were analyzed for CD4 and CD8 expressions; viability of the CD4⁺CD8⁺ cells was separately assessed with Live/Dead Cell Viability Assay (>95%). <b>B,</b> Proportions of total CD4⁺CD8⁺CD3⁺ (DPT) cells in peripheral blood and liver biopsy for each patient of the different groups. In grey, the experimental points with values above the thresholds (dashed lines) determined in (<b>C</b>), with the corresponding numbers of patients at the top (above threshold/total). <b>C,</b> Determination of the thresholds: 3% in the blood and 10% in the liver.