GRP94 deficiency in the bone marrow expanded the primitive cell pool.

<p>A) Representative flow cytometric analysis with BM cells using Lin, c-Kit, Sca-1, Flk2 and CD34. B) Quantitation of flow cytometric analysis of primitive cell proportions. Left panel shows the percentage of LSKFlk2⁻CD34⁻ in BM and right panel shows LSKFlk2⁻CD34⁺, LSKFlk2⁺ (n = 5 for WT, n = 8 for cKO) and total LSK (n = 16 for WT, n = 22 for cKO) cells in BM using Lin, c-Kit, Sca-1. C) Total BM cell number from WT (n = 19) and cKO (n = 20) mice (p = 0.373). All data are presented as mean ± s.e., **p<0.01, ***p<0.001.