Effect of PPADS on the time course of EEG changes in the delta- and alpha-frequency bands caused by permanent MCAO of rats in four cortical regions up to day 28 after permanent MCAO.

<p>The delta-frequency band is shown in the left panel (<b>A</b>, <b>C</b>, <b>E</b>, <b>G</b>) and the alpha-frequency band in the right panel (<b>B</b>, <b>D</b>, <b>F</b>, <b>H</b>). The inset shows the placement of the four cortical electrodes and the reference electrode. The electrode P2 is located above the expected ischemic area indicated by grey shading, whereas the other electrodes are located above the contralateral parietal cortex (P1) and the respective frontal cortices (F2 and F1). Data are calculated as percental changes of the relative power from baseline measurements and expressed as means ± SEM. (ACSF: n = 7; PPADS: n = 8), * <i>P</i><0.05, ** <i>P</i><0.001 <i>vs.</i> MCAO/ACSF; + <i>P</i><0.05 <i>vs.</i> day 1, # <i>P</i><0.01 <i>vs.</i> basal.