Histological examinations on day 14 of EAU.

<p>Images of histological analysis show obvious iris thickening, severe retinal folding, destruction, damage of the photoreceptor layer and massive inflammatory cell infiltration in the iris, vitreous, retina, and subretinal space, as well as intensive vasculitis formation in PBS injected eye (A, B) and AAV2.GFP injected eyes (C, D). However, a minor infiltration of inflammatory cells was observed in the vitreous and retina in both lower (E, F) and higher dose (G, H) of AAV2.hIFN-α treated eyes. (haematoxylin eosin staining, original magnification ×100) Histological grade (I) shows reduced EAU in both doses of AAV2.hIFN-α treated groups as compared with PBS injected and AAV2.GFP injected eyes (p<0.0001, Mann-Whitney U test). Each point is the score of an individual eye. The mean scores of each group are denoted by the horizontal bars.